![]() Selective serotonin reuptake inhibitors (SSRIs) have become the most widely used medicine in the world 7. At present, treatment of PE includes mainly psychotherapy, drug therapy and surgical treatment 6.ĭrug therapy is not only likely to be the most receptive approach for patients, but it is also the most commonly used method. Thus, it is important to treat patients with PE in order to improve quality of life. The role of PE on the individual and the sexual relationship is very significant. In addition, PE affects numerous aspects of a man's life, including sexual confidence, interpersonal relationships and the sexual satisfaction of both partners 5. Recently, the International Society for Sexual Medicine has proposed the following evidence-based definition: “PE is a male sexual dysfunction characterized by ejaculation that always or nearly always occurs prior to or within about 1 minute of vaginal penetration inability to delay ejaculation on all or nearly all vaginal penetrations and negative personal consequences, such as distress, bother, frustration, and/or the avoidance of sexual intimacy” 3, 4. Premature ejaculation (PE) is the most common male sexual dysfunction with a prevalence of between 20% and 40% 1, 2. We conclude that dapoxetine (particularly the 60 mg dosage) may be considered a safe and effective drug for patients with PE. The most common AEs were mild and tolerable. Our meta-analysis demonstrated that dapoxetine (in the 30 mg and 60 mg subgroup) resulted in significantly higher IELT, PGIC and AE incidence relative to the placebo, with higher proportions observed for 60 mg versus 30 mg of dapoxetine administration. Ultimately, a total of seven RCTs with 8039 patients were included. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC) and adverse effect (AE) incidence associated with the use of dapoxetine (30 mg and 60 mg) versus placebo and evaluate the differences in administering 60 mg versus 30 mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Dapoxetine hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. ![]() Premature ejaculation (PE) is the most common male sexual dysfunction.
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