![]() Tobacco Use and Dependence Guideline Panel. Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health 2004. The Health Consequences of Smoking: A Report of the Surgeon General. Effective tobacco control is key to rapid progress in reduction of non-communicable diseases. ![]() Effect of smoking cessation on mortality after myocardial infarction: meta-analysis of cohort studies. 21 st-Century hazards of smoking and benefits of cessation in the United States. Jha P, Ramasundarahettige C, Landsman V, Rostron B, Thun M, Anderson RN, McAfee T, Peto R. Peto R, Lopez AD, Boreham J, Thun M, Heath C, Doll R. When we examined major adverse cardiovascular events, we found a protective effect with bupropion (RR, 0.45 95% CI, 0.21–0.85) and no clear evidence of harm with varenicline (RR, 1.34 95% CI, 0.66–2.66) or nicotine replacement therapy (RR, 1.95 95% CI, 0.26–4.30). There was an elevated risk associated with nicotine replacement therapy that was driven predominantly by less serious events (RR, 2.29 95% CI, 1.39–3.82). Among 63 eligible RCTs involving 21 nicotine replacement therapy RCTs, 28 bupropion RCTs, and 18 varenicline RCTs, we found no increase in the risk of all cardiovascular disease events with bupropion (relative risk, 0.98 95% confidence interval, 0.54–1.73) or varenicline (RR, 1.30 95% CI, 0.79–2.23). We included any RCT of the 3 treatments that reported cardiovascular disease outcomes. ![]() We searched 10 electronic databases, were in communication with authors of published randomized, clinical trials (RCTs), and accessed internal US Food and Drug Administration reports. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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